ATP 250 · 2021-09-27 · draw of 32
San Diego 2021
HardFinal
| 🇳🇴 Casper Ruud | d. | 🇬🇧 Cameron Norrie | 6-0 6-2 | H2H |
Semifinals
| 🇬🇧 Cameron Norrie | d. | 🇷🇺 Andrey Rublev | 3-6 6-3 6-4 | H2H |
| 🇳🇴 Casper Ruud | d. | 🇧🇬 Grigor Dimitrov | 6-4 4-6 6-4 | H2H |
Quarterfinals
| 🇷🇺 Andrey Rublev | d. | 🇦🇷 Diego Schwartzman | 6-1 7-5 | H2H |
| 🇬🇧 Cameron Norrie | d. | 🇨🇦 Denis Shapovalov | 6-3 6-1 | H2H |
| 🇧🇬 Grigor Dimitrov | d. | 🇷🇺 Aslan Karatsev | 6-1 1-6 6-2 | H2H |
| 🇳🇴 Casper Ruud | d. | 🇮🇹 Lorenzo Sonego | 6-1 6-4 | H2H |
Round of 16
| 🇷🇺 Andrey Rublev | d. | 🇺🇸 Brandon Nakashima | 6-2 6-1 | H2H |
| 🇦🇷 Diego Schwartzman | d. | 🇿🇦 Lloyd Harris | 4-6 6-3 6-2 | H2H |
| 🇨🇦 Denis Shapovalov | d. | 🇺🇸 Taylor Fritz | 7-6(7) 6-2 | H2H |
| 🇬🇧 Cameron Norrie | d. | 🇬🇧 Daniel Evans | 7-6(3) 6-3 | H2H |
| 🇷🇺 Aslan Karatsev | d. | 🇵🇱 Hubert Hurkacz | 5-7 6-4 6-2 | H2H |
| 🇧🇬 Grigor Dimitrov | d. | 🇩🇰 August Holmgren | 6-1 6-1 | H2H |
| 🇮🇹 Lorenzo Sonego | d. | 🇺🇸 Sebastian Korda | 6-4 6-3 | H2H |
| 🇳🇴 Casper Ruud | d. | 🇬🇧 Andy Murray | 7-5 6-4 | H2H |
Round of 32
| 🇺🇸 Brandon Nakashima | d. | 🇮🇹 Fabio Fognini | 6-7(5) 6-1 7-5 | H2H |
| 🇿🇦 Lloyd Harris | d. | 🇺🇸 Christopher Eubanks | 3-6 6-1 6-4 | H2H |
| 🇦🇷 Diego Schwartzman | d. | 🇮🇹 Federico Gaio | 6-2 6-3 | H2H |
| 🇺🇸 Taylor Fritz | d. | 🇮🇹 Salvatore Caruso | 6-4 7-6(2) | H2H |
| 🇬🇧 Cameron Norrie | d. | 🇩🇪 Dominik Koepfer | 6-2 7-5 | H2H |
| 🇬🇧 Daniel Evans | d. | 🇿🇦 Kevin Anderson | 7-6(11) 7-5 | H2H |
| 🇵🇱 Hubert Hurkacz | d. | 🇦🇺 Alex Bolt | 7-6(2) 6-1 | H2H |
| 🇷🇺 Aslan Karatsev | d. | 🇦🇷 Federico Delbonis | 6-1 7-5 | H2H |
| 🇧🇬 Grigor Dimitrov | d. | 🇭🇺 Marton Fucsovics | 6-3 1-6 7-5 | H2H |
| 🇮🇹 Lorenzo Sonego | d. | 🇬🇪 Nikoloz Basilashvili | 6-3 6-4 | H2H |
| 🇺🇸 Sebastian Korda | d. | 🇺🇸 Tommy Paul | 6-3 5-7 6-1 | H2H |
| 🇬🇧 Andy Murray | d. | 🇺🇸 Denis Kudla | 6-3 6-2 | H2H |