ATP 500 · 2021-08-02 · draw of 64
Washington 2021
HardFinal
| 🇮🇹 Jannik Sinner | d. | 🇺🇸 Mackenzie McDonald | 7-5 4-6 7-5 | H2H |
Semifinals
| 🇺🇸 Mackenzie McDonald | d. | 🇯🇵 Kei Nishikori | 6-4 3-6 7-5 | H2H |
| 🇮🇹 Jannik Sinner | d. | 🇺🇸 Jenson Brooksby | 7-6(2) 6-1 | H2H |
Quarterfinals
| 🇯🇵 Kei Nishikori | d. | 🇿🇦 Lloyd Harris | 6-3 7-5 | H2H |
| 🇺🇸 Mackenzie McDonald | d. | 🇺🇸 Denis Kudla | 6-3 6-2 | H2H |
| 🇮🇹 Jannik Sinner | d. | 🇺🇸 Steve Johnson | 6-4 6-2 | H2H |
| 🇺🇸 Jenson Brooksby | d. | 🇦🇺 John Millman | 6-1 6-2 | H2H |
Round of 16
| 🇿🇦 Lloyd Harris | d. | 🇪🇸 Rafael Nadal | 6-4 1-6 6-4 | H2H |
| 🇯🇵 Kei Nishikori | d. | 🇬🇧 Cameron Norrie | 3-6 6-3 6-3 | H2H |
| 🇺🇸 Mackenzie McDonald | d. | 🇧🇾 Ilya Ivashka | 6-4 6-4 | H2H |
| 🇺🇸 Denis Kudla | d. | 🇺🇸 Brandon Nakashima | 3-6 7-6(3) 6-4 | H2H |
| 🇮🇹 Jannik Sinner | d. | 🇺🇸 Sebastian Korda | 7-6(3) 7-6(3) | H2H |
| 🇺🇸 Steve Johnson | d. | 🇱🇹 Ricardas Berankis | 6-2 6-1 | H2H |
| 🇦🇺 John Millman | d. | 🇺🇸 Reilly Opelka | 6-3 7-6(4) | H2H |
| 🇺🇸 Jenson Brooksby | d. | 🇨🇦 Felix Auger-Aliassime | 6-3 6-4 | H2H |
Round of 32
| 🇪🇸 Rafael Nadal | d. | 🇺🇸 Jack Sock | 6-2 4-6 7-6(1) | H2H |
| 🇿🇦 Lloyd Harris | d. | 🇺🇸 Tennys Sandgren | 6-4 1-0 RET | H2H |
| 🇯🇵 Kei Nishikori | d. | 🇰🇿 Alexander Bublik | 6-2 7-5 | H2H |
| 🇬🇧 Cameron Norrie | d. | 🇺🇸 Marcos Giron | 6-4 6-3 | H2H |
| 🇧🇾 Ilya Ivashka | d. | 🇧🇬 Grigor Dimitrov | 6-2 7-6(4) | H2H |
| 🇺🇸 Mackenzie McDonald | d. | 🇫🇷 Benoit Paire | 6-7(6) 6-4 6-4 | H2H |
| 🇺🇸 Denis Kudla | d. | 🇺🇸 Taylor Fritz | 6-4 6-2 | H2H |
| 🇺🇸 Brandon Nakashima | d. | 🇬🇧 Daniel Evans | 7-6(1) 6-0 | H2H |
| 🇮🇹 Jannik Sinner | d. | 🇫🇮 Emil Ruusuvuori | 6-2 6-4 | H2H |
| 🇺🇸 Sebastian Korda | d. | 🇨🇦 Vasek Pospisil | 7-5 6-4 | H2H |
| 🇱🇹 Ricardas Berankis | d. | 🇷🇸 Miomir Kecmanovic | 6-3 6-2 | H2H |
| 🇺🇸 Steve Johnson | d. | 🇦🇺 Alex de Minaur | 6-7(5) 6-4 6-2 | H2H |
| 🇺🇸 Reilly Opelka | d. | 🇨🇴 Daniel Elahi Galan | 7-6(1) 6-3 | H2H |
| 🇦🇺 John Millman | d. | 🇸🇪 Elias Ymer | 6-2 7-6(8) | H2H |
| 🇺🇸 Jenson Brooksby | d. | 🇺🇸 Frances Tiafoe | 7-6(4) 7-5 | H2H |
| 🇨🇦 Felix Auger-Aliassime | d. | 🇮🇹 Andreas Seppi | 2-6 6-2 6-2 | H2H |
Round of 64
| 🇺🇸 Jack Sock | d. | 🇯🇵 Yoshihito Nishioka | 6-7(3) 4-0 RET | H2H |
| 🇺🇸 Tennys Sandgren | d. | 🇦🇺 James Duckworth | 6-3 2-6 6-2 | H2H |
| 🇯🇵 Kei Nishikori | d. | 🇺🇸 Sam Querrey | 6-4 6-3 | H2H |
| 🇺🇸 Marcos Giron | d. | 🇺🇦 Illya Marchenko | 4-6 6-4 7-6(1) | H2H |
| 🇧🇾 Ilya Ivashka | d. | 🇧🇾 Egor Gerasimov | 7-5 6-4 | H2H |
| 🇺🇸 Mackenzie McDonald | d. | 🇦🇺 Nick Kyrgios | 6-4 6-4 | H2H |
| 🇺🇸 Denis Kudla | d. | 🇪🇸 Feliciano Lopez | 6-3 6-7(5) 6-3 | H2H |
| 🇺🇸 Brandon Nakashima | d. | 🇦🇺 Alexei Popyrin | 6-3 6-3 | H2H |
| 🇫🇮 Emil Ruusuvuori | d. | 🇮🇳 Prajnesh Gunneswaran | 2-6 6-1 6-1 | H2H |
| 🇨🇦 Vasek Pospisil | d. | 🇪🇨 Emilio Gomez | 4-6 6-3 6-3 | H2H |
| 🇱🇹 Ricardas Berankis | d. | 🇺🇸 Mitchell Krueger | 7-6(4) 6-2 | H2H |
| 🇺🇸 Steve Johnson | d. | 🇮🇳 Ramkumar Ramanathan | 6-3 7-6(0) | H2H |
| 🇨🇴 Daniel Elahi Galan | d. | 🇺🇸 Tommy Paul | 6-4 6-3 | H2H |
| 🇸🇪 Elias Ymer | d. | 🇦🇺 Jordan Thompson | 3-6 7-5 6-3 | H2H |
| 🇺🇸 Jenson Brooksby | d. | 🇿🇦 Kevin Anderson | 7-6(4) 6-3 | H2H |
| 🇮🇹 Andreas Seppi | d. | 🇯🇵 Yasutaka Uchiyama | 3-6 7-5 6-3 | H2H |